大学MOOC Computer-Aided Drug Design(Jinan University)1458196166 最新慕课完整章节测试答案
Chapter four Comprehensive case analysis
Unit test 4
1、单选题：
Homology modeling means that if a sequence is found to have ( ) with anoter sequence of known three-dimensional structure, then you can use the known structure to predict unknown three-dimensional structure by homology modeling
选项：
A: Similarity
B: Homology
C: Uniformity
D: Comparability
答案: 【 Homology】
2、单选题：
Homologous modeling is often used in protein structure prediction. Besides ab initio prediction, what is the other method ?
选项：
A: Specific configuration method
B: Reverse folding
C: Fragment method
D: Reference construction method
答案: 【 Reverse folding】
3、单选题：
Among the QSAR fitting correlation coefficients, there are three parameters including correlation coefficients R, standard deviation S and F test values. Which of the following statement is correct?
选项：
A: The larger R and F, the smaller s, indicating that the model fits better
B: The smaller R and F, the larger s, indicating the stronger the model's fitting ability
C: The smaller R is, the larger F is, and the smaller s is, indicating that the model fits better
D: The smaller R is, the larger F is, and the larger s is, indicating that the model fits better
答案: 【 The larger R and F, the smaller s, indicating that the model fits better】
4、多选题：
Which of the following methods could be used to the rigid molecular docking?
选项：
A: Method based on maximum group search
B: Method based on geometric hashing technology
C: Method based on pose clustering
D: Method based on Howard rule
答案: 【 Method based on maximum group search;
Method based on geometric hashing technology;
Method based on pose clustering】
5、多选题：
The flexible docking method includes which of the following methods
选项：
A: Ensemble method of conformation
B: Fragment method
C: Genetic algorithms and evolutionary programming
D: Method based on molecular simulation
答案: 【 Ensemble method of conformation;
Fragment method;
Genetic algorithms and evolutionary programming;
Method based on molecular simulation】
6、判断题：
Proteins need to be correctly folded into a specific configuration in order to perform their normal functions.
选项：
A: 正确
B: 错误
答案: 【 正确】
7、判断题：
The assumption of CoMSIA method is similar to that of CoMFA method, that is, the covalent interaction between ligand and receptor is determined by molecular field.