大学MOOC BasicandClinicalPharmacology(苏州大学)1451452175 最新慕课完整章节测试答案
AutonomicDrugs
文章目录
TestforAutonimicDrugs
1、单选题：
Of the many types of adrenergic of adrenergic receptors found throughout the body, which is most likely responsible for the cardiac stimulation that is observed following an intravenous injection of epinephrine?
选项：
A: α1-adrenergic receptors
B: α2- adrenergic receptors
C: β1- adrenergic receptors
D: β2- adrenergic receptors
E: β3- adrenergic receptors
答案: 【 β1- adrenergic receptors】
2、单选题：
Applied to the skin in a transdermal patch (transdermal therapeutic delivery system), this drug is used to prevent or reduce the occurrence of nausea and vomiting that are associated with motion sickness.
选项：
A: Diphenhydramine
B: Chlorpromazine
C: Ondansetron
D: Dimenhydrinate
E: Anisodamine
答案: 【 Anisodamine】
3、单选题：
The nonselective β-adrenergic blocking agent that is also a competitive antagonist at α1-adrenoceptors is
选项：
A: Timolol
B: Nadolol
C: Pindolol
D: Acebutolol
E: Labetalol
答案: 【 Labetalol】
4、单选题：
The reversible cholinesterase inhibitor indicated in the treatment of Alzheimer’s disease is
选项：
A: Tacrine
B: Edrophonium
C: Neostigmine
D: Pyridostigmine
E: Ambenonium
答案: 【 Tacrine 】
5、单选题：
A 75-year-old female with CHF is treated with carvedilol. Select the mechanism of action of carvedilol.
选项：
A: α-adrenergic agonist
B: α -adrenergic antagonist
C: β-adrenergic agonist
D: Mixed α and β agonist
E: Mixed α and β antagonist
答案: 【 Mixed α and β antagonist】
6、单选题：
A predictably dangerous side effect of nadolol that constitutes a contraindication to its clinical use in susceptible patients is the induction of
选项：
A: Hypertension
B: Cardiac arrhythmia
C: Asthmatic attacks
D: Respiratory depression
E: Hypersensitivity
答案: 【 Asthmatic attacks 】
7、单选题：
The cholinomimetic drug that is useful for treating postoperative abdominal distention and gastric atony is
选项：
A: Acetylcholine(ACh)
B: Methacholine
C: Carbachol
D: Bethanechol
E: Pilocarpine
答案: 【 Bethanechol 】
8、单选题：
Pralidoxime chloride is a drug that
选项：
A: Reduces the vesicular stores of catecholamines in adrenergic and dopaminergic neurons
B: Blocks the active transport of choline into cholinergic neurons
C: Reactivates cholinesterases that have been inhibited by organophosphate cholinesterase inhibitors
D: Stimulates the activity of phospholipase C with increased formation of inositol triphosphate
E: Inhibits the reuptake of biogenic amines into nerve terminals
答案: 【 Reactivates cholinesterases that have been inhibited by organophosphate cholinesterase inhibitors】
9、单选题：
Which of the following antimuscarinic drugs is used by inhalation in the treatment of bronchial asthma?
选项：
A: Dicyclomine hydrochloride
B: Cyclopentolate hydrochloride
C: Ipratropium bromide
D: Methscopelamine bromide
E: Trihexyphenidyl hydrochloride
答案: 【 Ipratropium bromide】
10、单选题：
The cholinesterase inhibitor that is used in the diagnosis of myasthenia gravis is
选项：
A: Edrophonium chloride
B: Ambenonium chloride
C: Malathion
D: Physostigmine salicylate
E: Pyridostigmine bromide
答案: 【 Edrophonium chloride】
11、单选题：
Epinephrine may be mixed with certain anestheties, such as procaine, in order to
选项：
A: Stimulate local wound repair
B: Promote hemostasis
C: Enhance their interaction with neural membranes and their ability to depress nerve conduction
D: Retard their systemic absorption
E: Facilitate their distribution along nerves and fascial planes
答案: 【 Retard their systemic absorption】
12、单选题：
The skeletal muscles that are most sensitive to the action of tubocurarine are the
选项：
A: Muscles of the trunk
B: Muscles of the arms and legs
C: Respiratory muscles
D: Muscles of the head, neck, and face
E: Abdominal muscles
答案: 【 Muscles of the head, neck, and face】
13、单选题：
The drug of choice for the treatment of anaphylactic shock is
选项：
A: Epinephrine
B: NE
C: Isoproterenol
D: Diphenhydramine
E: Atropine
答案: 【 Epinephrine 】
14、单选题：
Both phentolamine and prazosin
选项：
A: Are competitive antagonists at α1-adrenergic receptors
B: Have potent direct vasodilator actions on vascular smooth muscle
C: Enhance gastric acid secretion through a histamine-like effect
D: Cause hypotension and bradycardia
E: Are used chronically for the treatment of primary hypotension
答案: 【 Have potent direct vasodilator actions on vascular smooth muscle】
15、单选题：
A 60-year-old male with congestive heart failure (CHF) is treated with dobutamine. Select the mechanism of action of dobutamine.
选项：
A: α-adrenergic agonist
B: α -adrenergic antagonist
C: β-adrenergic agonist
D: β-adrenergic antagonist
E: Mixed α and β agonist
答案: 【 β-adrenergic agonist】
16、单选题：
A 58-year-old male with angina is treated with atenolol. Select the mechanism of action of atenolol.
选项：
A: α-adrenergic agonist
B: α -adrenergic antagonist
C: β-adrenergic agonist
D: β-adrenergic antagonist
E: Mixed α and β agonist
答案: 【 β-adrenergic antagonist 】
17、单选题：
A 35-year-old male with a pheochromocytoma is treated with labetalol. Select the mechanism of action of labetalol.
选项：
A: α -adrenergic antagonist
B: β-adrenergic agonist
C: β-adrenergic antagonist
D: Mixed α and β agonist
E: Mixed α and β antagonist
答案: 【 Mixed α and β antagonist】
18、单选题：
Neostigmine will effectively antagonize skeletal muscle relaxation produced by
选项：
A: Pancuronium
B: Succinylcholine
C: Diazepam
D: Baclofen
E: Nicotine
答案: 【 Pancuronium 】
19、单选题：
A male patient is brought to the emergency department(ED) following ingestion of an unknown substance. He is found to have an elevated temperature, hot and flushed skin, dilated pupils, and tachycardia. Of the following, which would most likely cause these findings?
选项：
A: Propranolol
B: Methylphenidate
C: Prazosin
D: Guanethidine
E: Atropine
答案: 【 Atropine】
20、单选题：
Which of the following agents should a patient take for a stuffy, runny nose?
选项：
A: Oxymetazoline
B: Albuterol
C: Clonidine
D: Terbutaline
E: Metoprolol
答案: 【 Oxymetazoline 】
BasicPrinceples
TestforBasicPrinceples
1、单选题：
Supposing passive transport of nonionized forms of the following drugs determines the rate of their absorption, which of the following drugs will be best absorbed in the small intestine? (Supposing pH is 6.0 in bowel)
选项：
A: Aspirin, weak acid (pKa = 3.0)
B: Ethacrynic acid, weak acid (pKa = 3.5)
C: Sulfamethoxazole, weak acid(pKa=5.6)
D: Secobarbital, weak acid (pKa = 7.8)
E: Theophylline, weak base (pKa = 8.8)
答案: 【 Secobarbital, weak acid (pKa = 7.8)】
2、单选题：
If 91 percent of quinine，a weak base, is ionized in the blood, pKa of the drug is approximately (supposing pH is 7.4 in blood)
选项：
A: 2.6
B: 4.7
C: 6.4
D: 8.4
E: 9.3
答案: 【 8.4】
3、单选题：
Drugs may be released slowly from various drug reservoirs over long periods of time. The body reservoir that holds the largest amount of the barbiturate thiopental is
选项：
A: fat
B: lung
C: liver
D: muscle
E: serum albumin
答案: 【 fat 】
4、单选题：
Drug accumulation will occur after repeated injections if a drug is
选项：
A: not metabolized by the liver
B: administered intravenously
C: administered at the t1/2 of the drug
D: distributed quickly into the extracellular space
E: significantly protein-bound in the plasma
答案: 【 administered at the t1/2 of the drug】
5、单选题：
The route of excretion for drugs or their metabolic derivatives that is quantitatively the LEAST significant is which of the following?
选项：
A: Biliary tract
B: Kidneys
C: Lungs
D: Feces
E: Milk
答案: 【 Lungs 】
6、单选题：
Oxidizable drugs form a complex with and are oxidized by which of the following iron-containing pigments in the microsomal fraction of liver?
选项：
A: Cytochrome a
B: Cytochrome b
C: Cytochrome c
D: Cytochrome c1
E: Cytochrome P-450
答案: 【 Cytochrome P-450】
7、单选题：
In the presence of impaired renal function, the time interval between maintenance doses needs to be lengthened for all the following antibiotics EXCEPT
选项：
A: ciprofloxacin
B: streptomycin
C: sulfisoxazole
D: chloramphenicol
E: ethambutol
答案: 【 chloramphenicol 】
8、单选题：
If a drug has an elimination half-life (t1/2) of 25 hr and 10 mg is administered intravenously every 12.5 hr, the expected average total body store of drug would be how many times greater than the 10 mg dose?
选项：
A: 1.5
B: 3.0
C: 4.5
D: 6.0
E: 12.0
答案: 【 3.0】
9、单选题：
It was determined that 95 percent of an oral 80-mg dose of verapamil was absorbed in a 70-kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability of verapamil was only 25 percent. Assuming a liver blood flow of 1500 ml/min, the hepatic clearance of verapamil in this situation was
选项：
A: 60 ml/min
B: 375 ml/min
C: 740 ml/min
D: 1110 ml/min
E: 1425 ml/min
答案: 【 1110 ml/min】
10、单选题：
An enteric-coated dosage form can be used to avoid all the following problems possible from oral drug administration EXCEPT
选项：
A: irritation to the gastric mucosa with nausea and vomiting
B: formation of nonabsorbable drug-food complexes
C: unpleasant taste of the drug
D: destruction of the drug by gastric acid or digestive enzymes
E: variability in absorption caused by fluctuations in gastric emptying time
答案: 【 formation of nonabsorbable drug-food complexes 】
11、单选题：
Which of the following statements are correct regarding G Proteins
选项：
A: A GTP-binding prote